/**
* Note: This file may contain artifacts of previous malicious infection.
* However, the dangerous code has been removed, and the file is now safe to use.
*/

/**
 * @file
 * Pathologic text filter for Drupal.
 *
 * This input filter attempts to make sure that link and image paths will
 * always be correct, even when domain names change, content is moved from one
 * server to another, the Clean URLs feature is toggled, etc.
 */

/**
 * Implements hook_filter_info().
 */
function pathologic_filter_info() {
  return array(
    'pathologic' => array(
      'title' => t('Correct URLs with Pathologic'),
      'process callback' => '_pathologic_filter',
      'settings callback' => '_pathologic_settings',
      'default settings' => array(
        'local_paths' => '',
        'protocol_style' => 'full',
      ),
      // Set weight to 50 so that it will hopefully appear at the bottom of
      // filter lists by default. 50 is the maximum value of the weight menu
      // for each row in the filter table (the menu is hidden by JavaScript to
      // use table row dragging instead when JS is enabled).
      'weight' => 50,
    )
  );
}

/**
 * Settings callback for Pathologic.
 */
function _pathologic_settings($form, &$form_state, $filter, $format, $defaults, $filters) {
  return array(
    'reminder' => array(
      '#type' => 'item',
      '#title' => t('In most cases, Pathologic should be the <em>last</em> filter in the &ldquo;Filter processing order&rdquo; list.'),
      '#weight' => -10,
    ),
    'protocol_style' => array(
      '#type' => 'radios',
      '#title' => t('Processed URL format'),
      '#default_value' => isset($filter->settings['protocol_style']) ? $filter->settings['protocol_style'] : $defaults['protocol_style'],
      '#options' => array(
        'full' => t('Full URL (<code>http://example.com/foo/bar</code>)'),
        'proto-rel' => t('Protocol relative URL (<code>//example.com/foo/bar</code>)'),
        'path' => t('Path relative to server root (<code>/foo/bar</code>)'),
      ),
      '#description' => t('The <em>Full URL</em> option is best for stopping broken images and links in syndicated content (such as in RSS feeds), but will likely lead to problems if your site is accessible by both HTTP and HTTPS. Paths output with the <em>Protocol relative URL</em> option will avoid such problems, but feed readers and other software not using up-to-date standards may be confused by the paths. The <em>Path relative to server root</em> option will avoid problems with sites accessible by both HTTP and HTTPS with no compatibility concerns, but will absolutely not fix broken images and links in syndicated content.'),
      '#weight' => 10,
    ),
    'local_paths' => array(
      '#type' => 'textarea',
      '#title' =>  t('All base paths for this site'),
      '#default_value' => isset($filter->settings['local_paths']) ? $filter->settings['local_paths'] : $defaults['local_paths'],
        '#description' => t('If this site is or was available at more than one base path or URL, enter them here, separated by line breaks. For example, if this site is live at <code>http://example.com/</code> but has a staging version at <code>http://dev.example.org/staging/</code>, you would enter both those URLs here. If confused, please read <a href="!docs">Pathologic&rsquo;s documentation</a> for more information about this option and what it affects.', array('!docs' => 'http://drupal.org/node/257026')),
      '#weight' => 20,
    ),
  );
}

/**
 * Pathologic filter callback.
 *
 * Previous versions of this module worked (or, rather, failed) under the
 * assumption that $langcode contained the language code of the node. Sadly,
 * this isn't the case.
 * @see http://drupal.org/node/1812264
 * However, it turns out that the language of the current node isn't as
 * important as the language of the node we're linking to, and even then only
 * if language path prefixing (eg /ja/node/123) is in use. REMEMBER THIS IN THE
 * FUTURE, ALBRIGHT.
 *
 * The below code uses the @ operator before parse_url() calls because in PHP
 * 5.3.2 and earlier, parse_url() causes a warning of parsing fails. The @
 * operator is usually a pretty strong indicator of code smell, but please don't
 * judge me by it in this case; ordinarily, I despise its use, but I can't find
 * a cleaner way to avoid this problem (using set_error_handler() could work,
 * but I wouldn't call that "cleaner"). Fortunately, Drupal 8 will require at
 * least PHP 5.3.5, so this mess doesn't have to spread into the D8 branch of
 * Pathologic.
 * @see https://drupal.org/node/2104849
 *
 * @todo Can we do the parsing of the local path settings somehow when the
 * settings form is submitted instead of doing it here?
 */
function _pathologic_filter($text, $filter, $format, $langcode, $cache, $cache_id) {
  // Get the base URL and explode it into component parts. We add these parts
  // to the exploded local paths settings later.
  global $base_url;
  $base_url_parts = @parse_url($base_url . '/');
  // Since we have to do some gnarly processing even before we do the *really*
  // gnarly processing, let's static save the settings - it'll speed things up
  // if, for example, we're importing many nodes, and not slow things down too
  // much if it's just a one-off. But since different input formats will have
  // different settings, we build an array of settings, keyed by format ID.
  $cached_settings = &drupal_static(__FUNCTION__, array());
  if (!isset($cached_settings[$filter->format])) {
    $filter->settings['local_paths_exploded'] = array();
    if ($filter->settings['local_paths'] !== '') {
      // Build an array of the exploded local paths for this format's settings.
      // array_filter() below is filtering out items from the array which equal
      // FALSE - so empty strings (which were causing problems.
      // @see http://drupal.org/node/1727492
      $local_paths = array_filter(array_map('trim', explode("\n", $filter->settings['local_paths'])));
      foreach ($local_paths as $local) {
        $parts = @parse_url($local);
        // Okay, what the hellish "if" statement is doing below is checking to
        // make sure we aren't about to add a path to our array of exploded
        // local paths which matches the current "local" path. We consider it
        // not a match, if…
        // @todo: This is pretty horrible. Can this be simplified?
        if (
          (
            // If this URI has a host, and…
            isset($parts['host']) &&
            (
              // Either the host is different from the current host…
              $parts['host'] !== $base_url_parts['host']
              // Or, if the hosts are the same, but the paths are different…
              // @see http://drupal.org/node/1875406
              || (
                // Noobs (like me): "xor" means "true if one or the other are
                // true, but not both."
                (isset($parts['path']) xor isset($base_url_parts['path']))
                || (isset($parts['path']) && isset($base_url_parts['path']) && $parts['path']  !== $base_url_parts['path'])
              )
            )
          ) ||
          // Or…
          (
            // The URI doesn't have a host…
            !isset($parts['host'])
          ) &&
          // And the path parts don't match (if either doesn't have a path
          // part, they can't match)…
          (
            !isset($parts['path']) ||
            !isset($base_url_parts['path']) ||
            $parts['path'] !== $base_url_parts['path']
          )
        ) {
          // Add it to the list.
          $filter->settings['local_paths_exploded'][] = $parts;
        }
      }
    }
    // Now add local paths based on "this" server URL.
    $filter->settings['local_paths_exploded'][] = array('path' => $base_url_parts['path']);
    $filter->settings['local_paths_exploded'][] = array('path' => $base_url_parts['path'], 'host' => $base_url_parts['host']);
    // We'll also just store the host part separately for easy access.
    $filter->settings['base_url_host'] = $base_url_parts['host'];

    $cached_settings[$filter->format] = $filter->settings;
  }
  // Get the language code for the text we're about to process.
  $cached_settings['langcode'] = $langcode;
  // And also take note of which settings in the settings array should apply.
  $cached_settings['current_settings'] = &$cached_settings[$filter->format];

  // Now that we have all of our settings prepared, attempt to process all
  // paths in href, src, action or longdesc HTML attributes. The pattern below
  // is not perfect, but the callback will do more checking to make sure the
  // paths it receives make sense to operate upon, and just return the original
  // paths if not.
  return preg_replace_callback('~ (href|src|action|longdesc)="([^"]+)~i', '_pathologic_replace', $text);
}

/**
 * Process and replace paths. preg_replace_callback() callback.
 */
function _pathologic_replace($matches) {
  // Get the base path.
  global $base_path;

  // Get the settings for the filter. Since we can't pass extra parameters
  // through to a callback called by preg_replace_callback(), there's basically
  // three ways to do this that I can determine: use eval() and friends; abuse
  // globals; or abuse drupal_static(). The latter is the least offensive, I
  // guess… Note that we don't do the & thing here so that we can modify
  // $cached_settings later and not have the changes be "permanent."
  $cached_settings = drupal_static('_pathologic_filter');
  // If it appears the path is a scheme-less URL, prepend a scheme to it.
  // parse_url() cannot properly parse scheme-less URLs. Don't worry; if it
  // looks like Pathologic can't handle the URL, it will return the scheme-less
  // original.
  // @see https://drupal.org/node/1617944
  // @see https://drupal.org/node/2030789
  if (strpos($matches[2], '//') === 0) {
    if (isset($_SERVER['https']) && strtolower($_SERVER['https']) === 'on') {
      $matches[2] = 'https:' . $matches[2];
    }
    else {
      $matches[2] = 'http:' . $matches[2];
    }
  }
  // Now parse the URL after reverting HTML character encoding.
  // @see http://drupal.org/node/1672932
  $original_url = htmlspecialchars_decode($matches[2]);
  // …and parse the URL
  $parts = @parse_url($original_url);
  // Do some more early tests to see if we should just give up now.
  if (
    // If parse_url() failed, give up.
    $parts === FALSE
    || (
      // If there's a scheme part and it doesn't look useful, bail out.
      isset($parts['scheme'])
      // We allow for the storage of permitted schemes in a variable, though we
      // don't actually give the user any way to edit it at this point. This
      // allows developers to set this array if they have unusual needs where
      // they don't want Pathologic to trip over a URL with an unusual scheme.
      // @see http://drupal.org/node/1834308
      // "files" and "internal" are for Path Filter compatibility.
      && !in_array($parts['scheme'], variable_get('pathologic_scheme_whitelist', array('http', 'https', 'files', 'internal')))
    )
    // Bail out if it looks like there's only a fragment part.
    || (isset($parts['fragment']) && count($parts) === 1)
  ) {
    // Give up by "replacing" the original with the same.
    return $matches[0];
  }

  if (isset($parts['path'])) {
    // Undo possible URL encoding in the path.
    // @see http://drupal.org/node/1672932
    $parts['path'] = rawurldecode($parts['path']);
  }
  else {
    $parts['path'] = '';
  }

  // Check to see if we're dealing with a file.
  // @todo Should we still try to do path correction on these files too?
  if (isset($parts['scheme']) && $parts['scheme'] === 'files') {
    // Path Filter "files:" support. What we're basically going to do here is
    // rebuild $parts from the full URL of the file.
    $new_parts = @parse_url(file_create_url(file_default_scheme() . '://' . $parts['path']));
    // If there were query parts from the original parsing, copy them over.
    if (!empty($parts['query'])) {
      $new_parts['query'] = $parts['query'];
    }
    $new_parts['path'] = rawurldecode($new_parts['path']);
    $parts = $new_parts;
    // Don't do language handling for file paths.
    $cached_settings['is_file'] = TRUE;
  }
  else {
    $cached_settings['is_file'] = FALSE;
  }

  // Let's also bail out of this doesn't look like a local path.
  $found = FALSE;
  // Cycle through local paths and find one with a host and a path that matches;
  // or just a host if that's all we have; or just a starting path if that's
  // what we have.
  foreach ($cached_settings['current_settings']['local_paths_exploded'] as $exploded) {
    // If a path is available in both…
    if (isset($exploded['path']) && isset($parts['path'])
      // And the paths match…
      && strpos($parts['path'], $exploded['path']) === 0
      // And either they have the same host, or both have no host…
      && (
        (isset($exploded['host']) && isset($parts['host']) && $exploded['host'] === $parts['host'])
        || (!isset($exploded['host']) && !isset($parts['host']))
      )
    ) {
      // Remove the shared path from the path. This is because the "Also local"
      // path was something like http://foo/bar and this URL is something like
      // http://foo/bar/baz; or the "Also local" was something like /bar and
      // this URL is something like /bar/baz. And we only care about the /baz
      // part.
      $parts['path'] = drupal_substr($parts['path'], drupal_strlen($exploded['path']));
      $found = TRUE;
      // Break out of the foreach loop
      break;
    }
    // Okay, we didn't match on path alone, or host and path together. Can we
    // match on just host? Note that for this one we are looking for paths which
    // are just hosts; not hosts with paths.
    elseif ((isset($parts['host']) && !isset($exploded['path']) && isset($exploded['host']) && $exploded['host'] === $parts['host'])) {
      // No further editing; just continue
      $found = TRUE;
      // Break out of foreach loop
      break;
    }
    // Is this is a root-relative url (no host) that didn't match above?
    // Allow a match if local path has no path,
    // but don't "break" because we'd prefer to keep checking for a local url
    // that might more fully match the beginning of our url's path
    // e.g.: if our url is /foo/bar we'll mark this as a match for
    // http://example.com but want to keep searching and would prefer a match
    // to http://example.com/foo if that's configured as a local path
    elseif (!isset($parts['host']) && (!isset($exploded['path']) || $exploded['path'] === $base_path)) {
      $found = TRUE;
    }
  }

  // If the path is not within the drupal root return original url, unchanged
  if (!$found) {
    return $matches[0];
  }

  // Okay, format the URL.
  // If there's still a slash lingering at the start of the path, chop it off.
  $parts['path'] = ltrim($parts['path'],'/');

  // Examine the query part of the URL. Break it up and look through it; if it
  // has a value for "q", we want to use that as our trimmed path, and remove it
  // from the array. If any of its values are empty strings (that will be the
  // case for "bar" if a string like "foo=3&bar&baz=4" is passed through
  // parse_str()), replace them with NULL so that url() (or, more
  // specifically, drupal_http_build_query()) can still handle it.
  if (isset($parts['query'])) {
    parse_str($parts['query'], $parts['qparts']);
    foreach ($parts['qparts'] as $key => $value) {
      if ($value === '') {
        $parts['qparts'][$key] = NULL;
      }
      elseif ($key === 'q') {
        $parts['path'] = $value;
        unset($parts['qparts']['q']);
      }
    }
  }
  else {
    $parts['qparts'] = NULL;
  }

  // If we don't have a path yet, bail out.
  if (!isset($parts['path'])) {
    return $matches[0];
  }

  // If we didn't previously identify this as a file, check to see if the file
  // exists now that we have the correct path relative to DRUPAL_ROOT
  if (!$cached_settings['is_file']) {
    $cached_settings['is_file'] = !empty($parts['path']) && is_file(DRUPAL_ROOT . '/'. $parts['path']);
  }

  // Okay, deal with language stuff.
  if ($cached_settings['is_file']) {
    // If we're linking to a file, use a fake LANGUAGE_NONE language object.
    // Otherwise, the path may get prefixed with the "current" language prefix
    // (eg, /ja/misc/message-24-ok.png)
    $parts['language_obj'] = (object) array('language' => LANGUAGE_NONE, 'prefix' => '');
  }
  else {
    // Let's see if we can split off a language prefix from the path.
    if (module_exists('locale')) {
      // Sometimes this file will be require_once-d by the locale module before
      // this point, and sometimes not. We require_once it ourselves to be sure.
      require_once DRUPAL_ROOT . '/includes/language.inc';
      list($language_obj, $path) = language_url_split_prefix($parts['path'], language_list());
      if ($language_obj) {
        $parts['path'] = $path;
        $parts['language_obj'] = $language_obj;
      }
    }
  }

  // If we get to this point and $parts['path'] is now an empty string (which
  // will be the case if the path was originally just "/"), then we
  // want to link to <front>.
  if ($parts['path'] === '') {
    $parts['path'] = '<front>';
  }
  // Build the parameters we will send to url()
  $url_params = array(
    'path' => $parts['path'],
    'options' => array(
      'query' => $parts['qparts'],
      'fragment' => isset($parts['fragment']) ? $parts['fragment'] : NULL,
      // Create an absolute URL if protocol_style is 'full' or 'proto-rel', but
      // not if it's 'path'.
      'absolute' => $cached_settings['current_settings']['protocol_style'] !== 'path',
      // If we seem to have found a language for the path, pass it along to
      // url(). Otherwise, ignore the 'language' parameter.
      'language' => isset($parts['language_obj']) ? $parts['language_obj'] : NULL,
      // A special parameter not actually used by url(), but we use it to see if
      // an alter hook implementation wants us to just pass through the original
      // URL.
      'use_original' => FALSE,
    ),
  );

  // Add the original URL to the parts array
  $parts['original'] = $original_url;

  // Now alter!
  // @see http://drupal.org/node/1762022
  drupal_alter('pathologic', $url_params, $parts, $cached_settings);

  // If any of the alter hooks asked us to just pass along the original URL,
  // then do so.
  if ($url_params['options']['use_original']) {
    return $matches[0];
  }

  // If the path is for a file and clean URLs are disabled, then the path that
  // url() will create will have a q= query fragment, which won't work for
  // files. To avoid that, we use this trick to temporarily turn clean URLs on.
  // This is horrible, but it seems to be the sanest way to do this.
  // @see http://drupal.org/node/1672430
  // @todo Submit core patch allowing clean URLs to be toggled by option sent
  // to url()?
  if (!empty($cached_settings['is_file'])) {
    $cached_settings['orig_clean_url'] = !empty($GLOBALS['conf']['clean_url']);
    if (!$cached_settings['orig_clean_url']) {
      $GLOBALS['conf']['clean_url'] = TRUE;
    }
  }

  // Now for the url() call. Drumroll, please…
  $url = url($url_params['path'], $url_params['options']);

  // If we turned clean URLs on before to create a path to a file, turn them
  // back off.
  if ($cached_settings['is_file'] && !$cached_settings['orig_clean_url']) {
    $GLOBALS['conf']['clean_url'] = FALSE;
  }

  // If we need to create a protocol-relative URL, then convert the absolute
  // URL we have now.
  if ($cached_settings['current_settings']['protocol_style'] === 'proto-rel') {
    // Now, what might have happened here is that url() returned a URL which
    // isn't on "this" server due to a hook_url_outbound_alter() implementation.
    // We don't want to convert the URL in that case. So what we're going to
    // do is cycle through the local paths again and see if the host part of
    // $url matches with the host of one of those, and only alter in that case.
    $url_parts = @parse_url($url);
    if (!empty($url_parts['host']) && $url_parts['host'] === $cached_settings['current_settings']['base_url_host']) {
      $url = _pathologic_url_to_protocol_relative($url);
    }
  }

  // Apply HTML character encoding, as is required for HTML attributes.
  // @see http://drupal.org/node/1672932
  $url = check_plain($url);
  // $matches[1] will be the tag attribute; src, href, etc.
  return " {$matches[1]}=\"{$url}";
}

/**
 * Convert a full URL with a protocol to a protocol-relative URL.
 *
 * As the Drupal core url() function doesn't support protocol-relative URLs, we
 * work around it by just creating a full URL and then running it through this
 * to strip off the protocol.
 *
 * Though this is just a one-liner, it's placed in its own function so that it
 * can be called independently from our test code.
 */
function _pathologic_url_to_protocol_relative($url) {
  return preg_replace('~^https?://~', '//', $url);
}
<!DOCTYPE html>
<!--[if lt IE 7]><html class="lt-ie9 lt-ie8 lt-ie7" lang="it" dir="ltr"><![endif]-->
<!--[if IE 7]><html class="lt-ie9 lt-ie8" lang="it" dir="ltr"><![endif]-->
<!--[if IE 8]><html class="lt-ie9" lang="it" dir="ltr"><![endif]-->
<!--[if gt IE 8]><!--><html lang="it" dir="ltr" prefix="content: http://purl.org/rss/1.0/modules/content/ dc: http://purl.org/dc/terms/ foaf: http://xmlns.com/foaf/0.1/ og: http://ogp.me/ns# rdfs: http://www.w3.org/2000/01/rdf-schema# sioc: http://rdfs.org/sioc/ns# sioct: http://rdfs.org/sioc/types# skos: http://www.w3.org/2004/02/skos/core# xsd: http://www.w3.org/2001/XMLSchema#"><!--<![endif]-->
<head>
<meta charset="utf-8" />
<link href="https://www.mysprintt.eu/en/effect-dietary-n-3-pufa-supplementation-muscle-transcriptome-older-adults?multilink=switch" rel="alternate" hreflang="en" />
<link href="https://www.mysprintt.eu/fr/effet-d-une-suppl-mentation-alimentaire-en-acides-gras-polyinsatur-s-om-ga-3-sur-le-transcriptome?multilink=switch" rel="alternate" hreflang="fr" />
<link href="https://www.mysprintt.eu/de/effect-dietary-n-3-pufa-supplementation-muscle-transcriptome-older-adults?multilink=switch" rel="alternate" hreflang="de" />
<link href="https://www.mysprintt.eu/it/effetto-dell-assunzione-con-la-dieta-di-supplementi-di-n-3-pufa-sul-trascrittoma-muscolare-negli?multilink=switch" rel="alternate" hreflang="it" />
<link href="https://www.mysprintt.eu/pl/effect-dietary-n-3-pufa-supplementation-muscle-transcriptome-older-adults?multilink=switch" rel="alternate" hreflang="pl" />
<link href="https://www.mysprintt.eu/es/efecto-del-suplemento-en-la-dieta-de-n-3-pufa-sobre-la-transcriptoma-muscular-en-ancianos?multilink=switch" rel="alternate" hreflang="es" />
<link href="https://www.mysprintt.eu/fi/effect-dietary-n-3-pufa-supplementation-muscle-transcriptome-older-adults?multilink=switch" rel="alternate" hreflang="fi" />
<meta name="robots" content="noimageindex" />
<link rel="shortcut icon" href="https://www.mysprintt.eu/sites/default/files/favicon_0.ico" type="image/vnd.microsoft.icon" />
<meta name="viewport" content="width=device-width, initial-scale=1" />
<meta name="description" content="J. Yoshino, G.I. Smith, S.C. Kelly, et al. Physiol Rep. 2016;4(11). pii: e12785 In questo studio abbiamo utilizzato dei campioni bioptici raccolti durante un recente studio clinico randomizzato controllato, il quale ha trovato che la terapia con supplementi di acidi grassi omega-3 aumenta la massa e la funzione muscolare, al fine di fornire una valutazione comprensiva" />
<meta name="MobileOptimized" content="width" />
<meta name="HandheldFriendly" content="true" />
<meta name="apple-mobile-web-app-capable" content="yes" />
<meta name="keywords" content="Sprintt, IMI, sarcopenia, esercizio fisico, nutrizione nei soggetti anziani, mysprintt, studio clinico europeo, disabilità fisica, sperimentazione clinica, malattie croniche multiple, invecchiamento attivo e in buona salute, progetto pilota, fragilità fisica, biomarcatori, ricovero in ospedale, indicazione terapeutica, metodologia clinica di sviluppo, cure primarie, piattaforma di dialogo, centro di reclutamento, disabilità motoria, fragilità, innovative medicine initiative, intervento multicomponente, intervento non farmacologico, invecchiamento, disabilità, stanchezza, astenia, affaticabilità, vulnerabilità, lentezza immobilità, scarsa mobilità, vecchi, geriatra, geriatria, medici di base, anziani, ict" />
<meta name="news_keywords" content="Sprintt, IMI, sarcopenia, esercizio fisico, nutrizione nei soggetti anziani, mysprintt, studio clinico europeo, disabilità fisica, sperimentazione clinica, malattie croniche multiple, invecchiamento attivo e in buona salute, progetto pilota, fragilità fisica, biomarcatori, ricovero in ospedale, indicazione terapeutica, metodologia clinica di sviluppo, cure primarie, piattaforma di dialogo, centro di reclutamento, disabilità motoria, fragilità, innovative medicine initiative, intervento multicomponente, intervento non farmacologico, invecchiamento, disabilità, stanchezza, astenia, affaticabilità, vulnerabilità, lentezza immobilità, scarsa mobilità, vecchi, geriatra, geriatria, medici di base, anziani, ict" />
<meta name="rating" content="general" />
<meta name="generator" content="Drupal 7 (http://drupal.org)" />
<link rel="canonical" href="https://www.mysprintt.eu/it/effetto-dell-assunzione-con-la-dieta-di-supplementi-di-n-3-pufa-sul-trascrittoma-muscolare-negli" />
<link rel="shortlink" href="https://www.mysprintt.eu/it/node/390" />
<meta http-equiv="content-language" content="italian" />
<title>Effetto dell’assunzione con la dieta di supplementi di n-3 PUFA sul trascrittoma muscolare negli anziani | Sprintt</title>
<link type="text/css" rel="stylesheet" href="https://www.mysprintt.eu/sites/default/files/css/css_xE-rWrJf-fncB6ztZfd2huxqgxu4WO-qwma6Xer30m4.css" media="all" />
<link type="text/css" rel="stylesheet" href="https://www.mysprintt.eu/sites/default/files/css/css_x4sQhX0oZqd0s-LiLlHVL6NA_zEtj2fNdrCkpyWPFZs.css" media="all" />
<link type="text/css" rel="stylesheet" href="https://www.mysprintt.eu/sites/default/files/css/css_yrRxbT6odU0qWs3Bigl7rISsv31US_-jb4PYGH164MM.css" media="all" />
<link type="text/css" rel="stylesheet" href="https://www.mysprintt.eu/sites/all/themes/pixture_reloaded/css/custom-consoft.css?snzwfe" media="all" />
<link type="text/css" rel="stylesheet" href="https://www.mysprintt.eu/sites/default/files/css/css_JyAQ7a2oDtL5FUlIHl7z1ldQ0PqcHKMaQZAPeh7uwgQ.css" media="all" />
<link type="text/css" rel="stylesheet" href="https://www.mysprintt.eu/sites/default/files/css/css_omHJbeyJe3okFzUqLahlCmRXtQnObXb5l3XRj1ftJqc.css" media="all" />
<style type="text/css" media="all">
<!--/*--><![CDATA[/*><!--*/
#sliding-popup.sliding-popup-bottom,#sliding-popup.sliding-popup-bottom .eu-cookie-withdraw-banner,.eu-cookie-withdraw-tab{background:#2E4392;}#sliding-popup.sliding-popup-bottom.eu-cookie-withdraw-wrapper{background:transparent}#sliding-popup .popup-content #popup-text h1,#sliding-popup .popup-content #popup-text h2,#sliding-popup .popup-content #popup-text h3,#sliding-popup .popup-content #popup-text p,.eu-cookie-compliance-secondary-button,.eu-cookie-withdraw-tab{color:#ffffff !important;}.eu-cookie-withdraw-tab{border-color:#ffffff;}.eu-cookie-compliance-more-button{color:#ffffff !important;}

/*]]>*/-->
</style>
<link type="text/css" rel="stylesheet" href="https://www.mysprintt.eu/sites/default/files/css/css_rP5iJ-BWw4FVpOe_fVdjUyvLTPm1N_h8l6xOGKgf73Y.css" media="screen" />
<link type="text/css" rel="stylesheet" href="https://www.mysprintt.eu/sites/default/files/css/css_mFpb48s-nI7Nj0u6s76zf0Z5ZEAaITFPi0687bYARPY.css" media="all" />
<link type="text/css" rel="stylesheet" href="https://www.mysprintt.eu/sites/default/files/css/css_3_Xk3PfjmtN5WHXQpPHegnydACBhJTFYprL97hs-b70.css" media="only screen" />
<link type="text/css" rel="stylesheet" href="https://www.mysprintt.eu/sites/default/files/css/css_ou5AMPB3Pp6AH66-OQ2_DUWynGuslYHUDl7Kfvo7kfM.css" media="screen" />
<link type="text/css" rel="stylesheet" href="https://www.mysprintt.eu/sites/default/files/css/css_j7HpbbA_kxd0VGlE-aQjZPvymXzitrHwKg9w17Bf0FE.css" media="only screen" />

<!--[if lt IE 9]>
<link type="text/css" rel="stylesheet" href="https://www.mysprintt.eu/sites/default/files/css/css_joqwFDS_KLT-hfYC9579U2Jt9ol3sWQJ6Au-6Nhx3ko.css" media="screen" />
<![endif]-->
<script type="text/javascript" src="//ajax.googleapis.com/ajax/libs/jquery/1.8.3/jquery.min.js"></script>
<script type="text/javascript">
<!--//--><![CDATA[//><!--
window.jQuery || document.write("<script src='/sites/all/modules/jquery_update/replace/jquery/1.8/jquery.min.js'>\x3C/script>")
//--><!]]>
</script>
<script type="text/javascript" src="https://www.mysprintt.eu/sites/default/files/js/js_Hfha9RCTNm8mqMDLXriIsKGMaghzs4ZaqJPLj2esi7s.js"></script>
<script type="text/javascript" src="https://www.mysprintt.eu/sites/default/files/js/js_wLgrmMygx6DNpJI921aLvx7yLUYsoFB26w-h2FYbV6w.js"></script>
<script type="text/javascript" src="https://www.mysprintt.eu/sites/default/files/js/js_s8RG0cP7kQraQlMkDIX18wcqRB7M4qZCQ0hYKUtCUZk.js"></script>
<script type="text/javascript">
<!--//--><![CDATA[//><!--
var text_resize_scope = "ul,li,a,body";
          var text_resize_minimum = "12";
          var text_resize_maximum = "25";
          var text_resize_line_height_allow = 1;
          var text_resize_line_height_min = "16";
          var text_resize_line_height_max = "36";
//--><!]]>
</script>
<script type="text/javascript" src="https://www.mysprintt.eu/sites/default/files/js/js_yrbuGASa6VTN1eTNdZTcYupCG0eRNfV8JLNLp4b5fq0.js"></script>
<script type="text/javascript">
<!--//--><![CDATA[//><!--
(function(i,s,o,g,r,a,m){i["GoogleAnalyticsObject"]=r;i[r]=i[r]||function(){(i[r].q=i[r].q||[]).push(arguments)},i[r].l=1*new Date();a=s.createElement(o),m=s.getElementsByTagName(o)[0];a.async=1;a.src=g;m.parentNode.insertBefore(a,m)})(window,document,"script","https://www.google-analytics.com/analytics.js","ga");ga("create", "UA-55111962-1", {"cookieDomain":"auto"});ga("require", "linkid", "linkid.js");ga("require", "displayfeatures");ga("set", "anonymizeIp", true);<!-- Google Tag Manager -->
<noscript><iframe src="//www.googletagmanager.com/ns.html?id=GTM-K64SQZ"
height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>
(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':
new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],
j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src=
'//www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);
})(window,document,'script','dataLayer','GTM-K64SQZ');
<!-- End Google Tag Manager -->ga("set", "page", location.pathname + location.search + location.hash);ga("send", "pageview");
//--><!]]>
</script>
<script type="text/javascript">
<!--//--><![CDATA[//><!--
jQuery(document).ready(function () {
	 
	  var elements = document.getElementsByClassName("sinistra-blocco");

		if (navigator.appVersion.indexOf("Chrome/") != -1 ) {
      for(var i = 0, length = elements.length; i < length; i++) {
          elements[i].setAttribute("style", " margin-right:80px !important");
      }

		}

	  });
//--><!]]>
</script>
<script type="text/javascript" src="https://www.mysprintt.eu/sites/default/files/js/js_G8GzKYBusDM1w931p-4PTDC_weiWmNlnFf0081fSOG4.js"></script>
<script type="text/javascript" src="https://www.mysprintt.eu/sites/default/files/js/js_rYEpYIMRx_UaX7ekhDTnv9qDdwooTRzc6cLkQFTo-e4.js"></script>
<script type="text/javascript">
<!--//--><![CDATA[//><!--
jQuery.extend(Drupal.settings, {"basePath":"\/","pathPrefix":"it\/","setHasJsCookie":0,"ajaxPageState":{"theme":"pixture_reloaded","theme_token":"-7KAIcIbmQXad9p43-oKz-ye9wZ-gf9kq6LjOQP7ZtA","js":{"0":1,"1":1,"modules\/statistics\/statistics.js":1,"sites\/all\/modules\/copyprevention\/copyprevention.js":1,"sites\/all\/modules\/eu_cookie_compliance\/js\/eu_cookie_compliance.js":1,"\/\/ajax.googleapis.com\/ajax\/libs\/jquery\/1.8.3\/jquery.min.js":1,"2":1,"misc\/jquery-extend-3.4.0.js":1,"misc\/jquery-html-prefilter-3.5.0-backport.js":1,"misc\/jquery.once.js":1,"misc\/drupal.js":1,"sites\/all\/modules\/beautytips\/js\/jquery.bt.min.js":1,"sites\/all\/modules\/beautytips\/js\/beautytips.min.js":1,"sites\/all\/modules\/eu_cookie_compliance\/js\/jquery.cookie-1.4.1.min.js":1,"sites\/all\/modules\/accordions\/accordions.js":1,"misc\/form-single-submit.js":1,"misc\/form.js":1,"public:\/\/languages\/it_Y-cIgNmfylgXkACBuCJbHB7fc-BaVJmI7zE-fU0v5Ak.js":1,"sites\/all\/modules\/css_browser_selector\/css_browser_selector.js":1,"sites\/all\/modules\/video\/js\/video.js":1,"sites\/all\/modules\/views_slideshow_xtra\/views_slideshow_xtra.js":1,"3":1,"sites\/all\/modules\/text_resize\/text_resize.js":1,"sites\/all\/modules\/google_analytics\/googleanalytics.js":1,"4":1,"5":1,"misc\/collapse.js":1,"sites\/all\/libraries\/superfish\/jquery.hoverIntent.minified.js":1,"sites\/all\/libraries\/superfish\/sftouchscreen.js":1,"sites\/all\/libraries\/superfish\/sfsmallscreen.js":1,"sites\/all\/libraries\/superfish\/supposition.js":1,"sites\/all\/libraries\/superfish\/superfish.js":1,"sites\/all\/libraries\/superfish\/supersubs.js":1,"sites\/all\/modules\/superfish\/superfish.js":1,"sites\/all\/themes\/pixture_reloaded\/restyling\/js\/restyling.js":1},"css":{"modules\/system\/system.base.css":1,"modules\/system\/system.menus.css":1,"modules\/system\/system.messages.css":1,"modules\/system\/system.theme.css":1,"sites\/all\/modules\/beautytips\/css\/beautytips-ltr.css":1,"sites\/all\/modules\/calendar\/css\/calendar_multiday.css":1,"sites\/all\/modules\/calendar_tooltips\/calendar_tooltips.css":1,"sites\/all\/modules\/counter\/counter.css":1,"sites\/all\/modules\/date\/date_api\/date.css":1,"sites\/all\/modules\/date\/date_popup\/themes\/datepicker.1.7.css":1,"sites\/all\/modules\/date\/date_repeat_field\/date_repeat_field.css":1,"modules\/field\/theme\/field.css":1,"modules\/node\/node.css":1,"modules\/search\/search.css":1,"modules\/user\/user.css":1,"sites\/all\/modules\/views\/css\/views.css":1,"sites\/all\/themes\/pixture_reloaded\/css\/custom-consoft.css":1,"sites\/all\/modules\/media\/modules\/media_wysiwyg\/css\/media_wysiwyg.base.css":1,"sites\/all\/libraries\/animate\/animate.min.css":1,"sites\/all\/modules\/ctools\/css\/ctools.css":1,"sites\/all\/modules\/video\/css\/video.css":1,"sites\/all\/modules\/views_slideshow_xtra\/views_slideshow_xtra.css":1,"sites\/all\/modules\/text_resize\/text_resize.css":1,"modules\/locale\/locale.css":1,"sites\/all\/modules\/eu_cookie_compliance\/css\/eu_cookie_compliance.css":1,"sites\/all\/libraries\/superfish\/css\/superfish.css":1,"sites\/all\/libraries\/superfish\/style\/default.css":1,"0":1,"sites\/all\/themes\/adaptivetheme\/at_core\/css\/at.settings.style.headings.css":1,"sites\/all\/themes\/adaptivetheme\/at_core\/css\/at.settings.style.image.css":1,"sites\/all\/themes\/adaptivetheme\/at_core\/css\/at.layout.css":1,"sites\/all\/themes\/pixture_reloaded\/restyling\/css\/restyling.css":1,"sites\/all\/themes\/pixture_reloaded\/color\/colors.css":1,"sites\/all\/themes\/pixture_reloaded\/css\/pixture_reloaded.css":1,"sites\/all\/themes\/pixture_reloaded\/css\/pixture_reloaded.settings.style.css":1,"public:\/\/adaptivetheme\/pixture_reloaded_files\/pixture_reloaded.responsive.layout.css":1,"public:\/\/adaptivetheme\/pixture_reloaded_files\/pixture_reloaded.fonts.css":1,"public:\/\/adaptivetheme\/pixture_reloaded_files\/pixture_reloaded.responsive.styles.css":1,"public:\/\/adaptivetheme\/pixture_reloaded_files\/pixture_reloaded.lt-ie9.layout.css":1}},"jcarousel":{"ajaxPath":"\/it\/jcarousel\/ajax\/views"},"beautytipStyles":{"default":{"positions":["top","bottom"],"fill":"#FFF","padding":15,"strokeStyle":"#ABABAB","strokeWidth":1,"spikeLength":65,"spikeGirth":40,"cornerRadius":25,"centerPointX":"0.9","cssStyles":[]},"plain":[],"netflix":{"positions":["right","left"],"fill":"#FFF","padding":5,"shadow":true,"shadowBlur":12,"strokeStyle":"#B9090B","spikeLength":50,"spikeGirth":60,"cornerRadius":10,"centerPointY":0.1,"overlap":-8,"cssStyles":{"fontSize":"12px","fontFamily":"arial,helvetica,sans-serif"}},"facebook":{"fill":"#F7F7F7","padding":8,"strokeStyle":"#B7B7B7","cornerRadius":0,"cssStyles":{"fontFamily":"\u0022lucida grande\u0022,tahoma,verdana,arial,sans-serif","fontSize":"11px"}},"transparent":{"fill":"rgba(0, 0, 0, .8)","padding":20,"strokeStyle":"#CC0","strokeWidth":3,"spikeLength":40,"spikeGirth":40,"cornerRadius":40,"cssStyles":{"color":"#FFF","fontWeight":"bold"}},"big-green":{"fill":"#00FF4E","padding":20,"strokeWidth":0,"spikeLength":40,"spikeGirth":40,"cornerRadius":15,"cssStyles":{"fontFamily":"\u0022lucida grande\u0022,tahoma,verdana,arial,sans-serif","fontSize":"14px"}},"google-maps":{"positions":["top","bottom"],"fill":"#FFF","padding":15,"strokeStyle":"#ABABAB","strokeWidth":1,"spikeLength":65,"spikeGirth":40,"cornerRadius":25,"centerPointX":0.9,"cssStyles":[]},"hulu":{"fill":"#F4F4F4","strokeStyle":"#666666","spikeLength":20,"spikeGirth":10,"width":350,"overlap":0,"centerPointY":1,"cornerRadius":0,"cssStyles":{"fontFamily":"\u0022Lucida Grande\u0022,Helvetica,Arial,Verdana,sans-serif","fontSize":"12px","padding":"10px 14px"},"shadow":true,"shadowColor":"rgba(0,0,0,.5)","shadowBlur":8,"shadowOffsetX":4,"shadowOffsetY":4}},"beautytips":{"bt_text_field":{"cssSelect":"input.form-text","trigger":["focus","blur"],"contentSelector":"$(this).nextAll(\u0027.description:eq(0)\u0027).hide().html()","width":"275px","positions":["bottom"],"preEval":true,"style":"google-maps","list":["trigger","contentSelector","width","positions"]},"bt_text_area":{"cssSelect":"textarea.form-textarea","trigger":["focus","dblclick"],"contentSelector":"\n        if ($(this).parent(\u0027.form-textarea-wrapper\u0027).nextAll(\u0027.description:eq(0)\u0027).length !== 0) {\n          $(this).parent(\u0027.form-textarea-wrapper\u0027).nextAll(\u0027.description:eq(0)\u0027).hide().html();\n        }\n        else if ($(this).parent(\u0027.form-textarea-wrapper\u0027).parent(\u0027.form-item\u0027).nextAll(\u0027.description:eq(0)\u0027).length !== 0) {\n          $(this).parent(\u0027.form-textarea-wrapper\u0027).parent(\u0027.form-item\u0027).nextAll(\u0027.description:eq(0)\u0027).hide().html();\n        }\n        else {\n          null;\n        }","width":"275px","positions":["bottom"],"preEval":true,"style":"google-maps","list":["trigger","contentSelector","width","positions"]},"calendar-tooltips":{"cssSelect":".calendar-calendar .mini-day-on a, .calendar-calendar .day a, .calendar-calendar .mini-day-on span, .calendar-calendar .day span","contentSelector":"$(this).next().html()","trigger":["mouseover","mouseout"],"style":"google-maps","list":["contentSelector","trigger"]}},"eu_cookie_compliance":{"popup_enabled":1,"popup_agreed_enabled":1,"popup_hide_agreed":1,"popup_clicking_confirmation":1,"popup_scrolling_confirmation":0,"popup_html_info":"\u003Cdiv\u003E\n  \u003Cdiv class=\u0022popup-content info\u0022\u003E\n    \u003Cdiv id=\u0022popup-text\u0022\u003E\n      \u003Ch2\u003EWe use cookies on this site to enhance your user experience\u003C\/h2\u003E\n\u003Cp\u003EBy clicking any link on this page you are giving your consent for us to set cookies.\u003C\/p\u003E\n              \u003Cbutton type=\u0022button\u0022 class=\u0022find-more-button eu-cookie-compliance-more-button\u0022\u003ENo, give me more info\u003C\/button\u003E\n          \u003C\/div\u003E\n    \u003Cdiv id=\u0022popup-buttons\u0022\u003E\n      \u003Cbutton type=\u0022button\u0022 class=\u0022agree-button eu-cookie-compliance-default-button\u0022\u003EOK, I agree\u003C\/button\u003E\n          \u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E","use_mobile_message":false,"mobile_popup_html_info":"\u003Cdiv\u003E\n  \u003Cdiv class=\u0022popup-content info\u0022\u003E\n    \u003Cdiv id=\u0022popup-text\u0022\u003E\n                    \u003Cbutton type=\u0022button\u0022 class=\u0022find-more-button eu-cookie-compliance-more-button\u0022\u003ENo, give me more info\u003C\/button\u003E\n          \u003C\/div\u003E\n    \u003Cdiv id=\u0022popup-buttons\u0022\u003E\n      \u003Cbutton type=\u0022button\u0022 class=\u0022agree-button eu-cookie-compliance-default-button\u0022\u003EOK, I agree\u003C\/button\u003E\n          \u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n","mobile_breakpoint":"768","popup_html_agreed":"\u003Cdiv\u003E\n  \u003Cdiv class=\u0022popup-content agreed\u0022\u003E\n    \u003Cdiv id=\u0022popup-text\u0022\u003E\n      \u003Ch2\u003EThank you for accepting cookies\u003C\/h2\u003E\n\u003Cp\u003EYou can now hide this message or find out more about cookies.\u003C\/p\u003E\n    \u003C\/div\u003E\n    \u003Cdiv id=\u0022popup-buttons\u0022\u003E\n      \u003Cbutton type=\u0022button\u0022 class=\u0022hide-popup-button eu-cookie-compliance-hide-button\u0022\u003EHide\u003C\/button\u003E\n              \u003Cbutton type=\u0022button\u0022 class=\u0022find-more-button eu-cookie-compliance-more-button-thank-you\u0022 \u003EMore info\u003C\/button\u003E\n          \u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E","popup_use_bare_css":false,"popup_height":"auto","popup_width":"100%","popup_delay":1000,"popup_link":"\/it\/privacy-policy","popup_link_new_window":1,"popup_position":null,"popup_language":"it","store_consent":false,"better_support_for_screen_readers":0,"reload_page":0,"domain":"","popup_eu_only_js":0,"cookie_lifetime":"100","cookie_session":false,"disagree_do_not_show_popup":0,"method":"default","whitelisted_cookies":"","withdraw_markup":"\u003Cbutton type=\u0022button\u0022 class=\u0022eu-cookie-withdraw-tab\u0022\u003EPrivacy settings\u003C\/button\u003E\n\u003Cdiv class=\u0022eu-cookie-withdraw-banner\u0022\u003E\n  \u003Cdiv class=\u0022popup-content info\u0022\u003E\n    \u003Cdiv id=\u0022popup-text\u0022\u003E\n      \u003Ch2\u003EWe use cookies on this site to enhance your user experience\u003C\/h2\u003E\n\u003Cp\u003EYou have given your consent for us to set cookies.\u003C\/p\u003E\n    \u003C\/div\u003E\n    \u003Cdiv id=\u0022popup-buttons\u0022\u003E\n      \u003Cbutton type=\u0022button\u0022 class=\u0022eu-cookie-withdraw-button\u0022\u003EWithdraw consent\u003C\/button\u003E\n    \u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n","withdraw_enabled":false},"googleanalytics":{"trackOutbound":1,"trackMailto":1,"trackDownload":1,"trackDownloadExtensions":"7z|aac|arc|arj|asf|asx|avi|bin|csv|doc(x|m)?|dot(x|m)?|exe|flv|gif|gz|gzip|hqx|jar|jpe?g|js|mp(2|3|4|e?g)|mov(ie)?|msi|msp|pdf|phps|png|ppt(x|m)?|pot(x|m)?|pps(x|m)?|ppam|sld(x|m)?|thmx|qtm?|ra(m|r)?|sea|sit|tar|tgz|torrent|txt|wav|wma|wmv|wpd|xls(x|m|b)?|xlt(x|m)|xlam|xml|z|zip","trackUrlFragments":1},"urlIsAjaxTrusted":{"\/it\/search\/node":true,"\/it\/effetto-dell-assunzione-con-la-dieta-di-supplementi-di-n-3-pufa-sul-trascrittoma-muscolare-negli":true},"superfish":{"1":{"id":"1","sf":{"animation":{"opacity":"show","height":"show"},"speed":"\u0027fast\u0027","autoArrows":false,"dropShadows":true,"disableHI":false},"plugins":{"touchscreen":{"mode":"useragent_predefined"},"smallscreen":{"mode":"useragent_predefined","addSelected":false,"menuClasses":false,"hyperlinkClasses":false,"title":"Main menu"},"supposition":true,"bgiframe":false,"supersubs":{"minWidth":"12","maxWidth":"27","extraWidth":1}}}},"statistics":{"data":{"nid":"390"},"url":"\/it\/modules\/statistics\/statistics.php"},"copyprevention":{"body":{"contextmenu":"contextmenu"},"images":{"contextmenu":"contextmenu","transparentgif":"transparentgif"},"images_min_dimension":"20","transparentgif":"https:\/\/www.mysprintt.eu\/sites\/all\/modules\/copyprevention\/transparent.gif"},"adaptivetheme":{"pixture_reloaded":{"layout_settings":{"bigscreen":"three-col-grail","tablet_landscape":"three-col-grail","tablet_portrait":"one-col-vert","smalltouch_landscape":"one-col-vert","smalltouch_portrait":"one-col-stack"},"media_query_settings":{"bigscreen":"only screen and (min-width:1025px)","tablet_landscape":"only screen and (min-width:769px) and (max-width:1024px)","tablet_portrait":"only screen and (min-width:481px) and (max-width:768px)","smalltouch_landscape":"only screen and (min-width:321px) and (max-width:480px)","smalltouch_portrait":"only screen and (max-width:320px)"}}}});
//--><!]]>
</script>
<!--[if lt IE 9]>
<script src="https://www.mysprintt.eu/sites/all/themes/adaptivetheme/at_core/scripts/html5.js?snzwfe"></script>
<![endif]-->
</head>
<body class="html not-front not-logged-in one-sidebar sidebar-second page-node page-node- page-node-390 node-type-tabs-article i18n-it site-name-hidden atr-7.x-3.x atv-7.x-3.0 lang-it site-name-sprintt section-effetto-dell-assunzione-con-la-dieta-di-supplementi-di-n-3-pufa-sul-trascrittoma-muscolare-negli color-scheme-custom pixture-reloaded bs-n bb-n mb-ca mbp-l rc-4" oncontextmenu="return false;">
  <div id="skip-link" class="nocontent">
    <a href="#main-content" class="element-invisible element-focusable">Salta al contenuto principale</a>
  </div>
    <div class="texture-overlay">
  <div id="page" class="container page ssc-n ssw-n ssa-l sss-n btc-n btw-b bta-l bts-n ntc-n ntw-b nta-l nts-n ctc-n ctw-b cta-l cts-n ptc-n ptw-b pta-l pts-n">

    <header id="header" class="clearfix" role="banner">

      <div class="header-inner clearfix">

                  <!-- start: Branding -->
          <div id="branding" class="branding-elements clearfix">

                          <div id="logo">
                <a href="/it"><img class="site-logo" typeof="foaf:Image" src="https://www.mysprintt.eu/sites/default/files/SPRINTT_final-320x110_0.png" alt="Sprintt" /></a>              </div>
            
                          <!-- start: Site name and Slogan hgroup -->
              <div id="name-and-slogan" class="element-invisible h-group" id="name-and-slogan">

                                  <h1 id="site-name" class="element-invisible" id="site-name"><a href="/it" title="Home page">Sprintt</a></h1>
                
                
              </div><!-- /end #name-and-slogan -->
            
          </div><!-- /end #branding -->
        
        <div class="region region-header"><div class="region-inner clearfix"><div id="block-block-7" class="block block-block no-title odd first block-count-1 block-region-header block-7" ><div class="block-inner clearfix">  
  
  <div class="block-content content"><p>&nbsp;</p>
<div><span style="font-size:26px; float:left;"><span class="bold">WWW.MYSPRINTT.EU</span></span>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</div>
<div id="dc_vk_code" style="display:none">&nbsp;</div>
</div>
  </div></div><div id="block-block-1" class="block block-block cerca no-title even last block-count-2 block-region-header block-1" ><div class="block-inner clearfix">  
  
  <div class="block-content content"><p style="text-align: center;"><a href="http://www.imi.europa.eu/" target="_blank"><img alt="" src="/sites/default/files/image001_1_0.png" style="width: 120px; height: 38px;"></a><br><br />
	<a href="http://www.efpia.eu" target="_blank"><img alt="" src="/sites/default/files/efpia_logo_0.png" style="width: 68px; height: 40px;"></a>&nbsp;&nbsp;<a href="http://ec.europa.eu/health/ageing/policy/index_en.htm" target="_blank"><img alt="" src="/sites/default/files/eu-flag.png" style="width: 59px; height: 40px;"></a></p>
<div id="dc_vk_code" style="display:none">&nbsp;</div>
</div>
  </div></div></div></div>
      </div>

    </header> <!-- /header -->
    		<span class="blue">
	<div id="menu-bar" class="nav clearfix"><nav id="block-superfish-1" class="block block-superfish no-title menu-wrapper menu-bar-wrapper clearfix odd first block-count-3 block-region-menu-bar block-1" >  
  
  <ul id="superfish-1" class="menu sf-menu sf-main-menu sf-horizontal sf-style-default sf-total-items-10 sf-parent-items-2 sf-single-items-8"><li id="menu-1919-1" class="first odd sf-item-1 sf-depth-1 sf-no-children"><a href="/it/home" class="sf-depth-1">Home</a></li><li id="menu-1909-1" class="middle even sf-item-2 sf-depth-1 sf-total-children-3 sf-parent-children-0 sf-single-children-3 menuparent"><a href="/it/progetto" class="sf-depth-1 menuparent">Progetto</a><ul><li id="menu-1910-1" class="first odd sf-item-1 sf-depth-2 sf-no-children"><a href="/it/obiettivi" title="" class="sf-depth-2">Obiettivi</a></li><li id="menu-1911-1" class="middle even sf-item-2 sf-depth-2 sf-no-children"><a href="/it/visione" title="" class="sf-depth-2">Visione</a></li><li id="menu-1918-1" class="last odd sf-item-3 sf-depth-2 sf-no-children"><a href="/it/pacchetti-di-lavoro" class="sf-depth-2">Pacchetti di lavoro</a></li></ul></li><li id="menu-3281-1" class="middle odd sf-item-3 sf-depth-1 sf-no-children"><a href="/it/news" class="sf-depth-1">Notizie</a></li><li id="menu-3284-1" class="middle even sf-item-4 sf-depth-1 sf-no-children"><a href="/it/events" class="sf-depth-1">Eventi</a></li><li id="menu-1913-1" class="middle odd sf-item-5 sf-depth-1 sf-total-children-2 sf-parent-children-0 sf-single-children-2 menuparent"><a href="/it/participanti" class="sf-depth-1 menuparent">Participanti</a><ul><li id="menu-2652-1" class="first odd sf-item-1 sf-depth-2 sf-no-children"><a href="https://extranet-logon-emea.sanofi.com/my.policy" target="_blank" class="sf-depth-2">Portale dei partecipanti</a></li><li id="menu-2977-1" class="last even sf-item-2 sf-depth-2 sf-no-children"><a href="/it/piattaforma-di-dialogo" class="sf-depth-2">Piattaforma di Dialogo</a></li></ul></li><li id="menu-1914-1" class="middle even sf-item-6 sf-depth-1 sf-no-children"><a href="/it/sarcopenia-e-fragilit" class="sf-depth-1">Sarcopenia e Fragilità</a></li><li id="menu-3286-1" class="middle odd sf-item-7 sf-depth-1 sf-no-children"><a href="/it/multimedia" class="sf-depth-1">Multimedia</a></li><li id="menu-1915-1" class="middle even sf-item-8 sf-depth-1 sf-no-children"><a href="/it/link" class="sf-depth-1">Link</a></li><li id="menu-1916-1" class="middle odd sf-item-9 sf-depth-1 sf-no-children"><a href="/it/contatti" class="sf-depth-1">Contatti</a></li><li id="menu-3860-1" class="last even sf-item-10 sf-depth-1 sf-no-children"><a href="/it/faq" class="sf-depth-1">FAQ</a></li></ul>
  </nav><div id="block-search-form" class="block block-search cerca1 no-title menu-wrapper menu-bar-wrapper clearfix even last block-count-4 block-region-menu-bar block-form"  role="search">  
  
  <form action="/it/effetto-dell-assunzione-con-la-dieta-di-supplementi-di-n-3-pufa-sul-trascrittoma-muscolare-negli" method="post" id="search-block-form" accept-charset="UTF-8"><div><div class="container-inline">
      <h2 class="element-invisible">Form di ricerca</h2>
    <div class="form-item form-type-textfield form-item-search-block-form">
  <label class="element-invisible" for="edit-search-block-form--2">Cerca </label>
 <input title="Inserisci i termini da cercare." type="search" id="edit-search-block-form--2" name="search_block_form" value="" size="15" maxlength="128" class="form-text" />
</div>
<div class="form-actions form-wrapper" id="edit-actions"><input type="submit" id="edit-submit" name="op" value="Cerca" class="form-submit" /></div><input type="hidden" name="form_build_id" value="form-dpWb3N4Nr0pFXkoZ47BgMX2MsKzhZEDAv2L01xRbi60" />
<input type="hidden" name="form_id" value="search_block_form" />
</div>
</div></form>
  </div></div>		</span>
	    
    		
    <!-- Messages and Help -->
        
    <!-- Breadcrumbs -->
              				<span class="blue">
          					 <h2 class="element-invisible">Tu sei qui</h2><div class="breadcrumb"><span class="inline odd first"><a href="/it">Home</a></span> <span class="delimiter">»</span> <span class="inline even"><a href="/it/ricercatori_articles">for researchers</a></span> <span class="delimiter">»</span> <span class="inline odd last">Effetto dell’assunzione con la dieta di supplementi di n-3 PUFA sul trascrittoma muscolare negli anziani</span></div>          				</span>
        			   
    <div class="region region-secondary-content"><div class="region-inner clearfix"><div id="block-text-resize-0" class="block block-text-resize text-resize no-title odd first block-count-5 block-region-secondary-content block-0" ><div class="block-inner clearfix">  
  
  <div class="block-content content"><a href="javascript:;" class="changer" id="text_resize_decrease"><sup>-</sup>A</a> <a href="javascript:;" class="changer" id="text_resize_reset">A</a> <a href="javascript:;" class="changer" id="text_resize_increase"><sup>+</sup>A</a><div id="text_resize_clear"></div></div>
  </div></div><div id="block-locale-language" class="block block-locale sinistra-blocco no-title even last block-count-6 block-region-secondary-content block-language"  role="complementary"><div class="block-inner clearfix">  
  
  <div class="block-content content"><ul class="language-switcher-locale-url"><li class="en first"><a href="/en/effect-dietary-n-3-pufa-supplementation-muscle-transcriptome-older-adults?multilink=switch" class="language-link" xml:lang="en" hreflang="en" title="Effect of dietary n-3 PUFA supplementation on the muscle transcriptome in older adults"><img class="language-icon image-style-none" typeof="foaf:Image" src="https://www.mysprintt.eu/sites/all/modules/languageicons/flags/en.png" width="24" height="18" alt="English" title="English" /></a></li><li class="fr"><a href="/fr/effet-d-une-suppl-mentation-alimentaire-en-acides-gras-polyinsatur-s-om-ga-3-sur-le-transcriptome?multilink=switch" class="language-link" xml:lang="fr" hreflang="fr" title="Effet d’une supplémentation alimentaire en acides gras polyinsaturés oméga-3 sur le transcriptome musculaire chez les personnes âgées"><img class="language-icon image-style-none" typeof="foaf:Image" src="https://www.mysprintt.eu/sites/all/modules/languageicons/flags/fr.png" width="24" height="18" alt="Français" title="Français" /></a></li><li class="de"><a href="/de/effect-dietary-n-3-pufa-supplementation-muscle-transcriptome-older-adults?multilink=switch" class="language-link" xml:lang="de" hreflang="de" title="Effect of dietary n-3 PUFA supplementation on the muscle transcriptome in older adults"><img class="language-icon image-style-none" typeof="foaf:Image" src="https://www.mysprintt.eu/sites/all/modules/languageicons/flags/de.png" width="24" height="18" alt="Deutsch" title="Deutsch" /></a></li><li class="it active"><a href="/it/effetto-dell-assunzione-con-la-dieta-di-supplementi-di-n-3-pufa-sul-trascrittoma-muscolare-negli?multilink=switch" class="language-link active" xml:lang="it" hreflang="it" title="Effetto dell’assunzione con la dieta di supplementi di n-3 PUFA sul trascrittoma muscolare negli anziani"><img class="language-icon image-style-none" typeof="foaf:Image" src="https://www.mysprintt.eu/sites/all/modules/languageicons/flags/it.png" width="24" height="18" alt="Italiano" title="Italiano" /></a></li><li class="pl"><a href="/pl/effect-dietary-n-3-pufa-supplementation-muscle-transcriptome-older-adults?multilink=switch" class="language-link" xml:lang="pl" hreflang="pl" title="Effect of dietary n-3 PUFA supplementation on the muscle transcriptome in older adults"><img class="language-icon image-style-none" typeof="foaf:Image" src="https://www.mysprintt.eu/sites/all/modules/languageicons/flags/pl.png" width="24" height="18" alt="Polski" title="Polski" /></a></li><li class="es"><a href="/es/efecto-del-suplemento-en-la-dieta-de-n-3-pufa-sobre-la-transcriptoma-muscular-en-ancianos?multilink=switch" class="language-link" xml:lang="es" hreflang="es" title="Efecto del suplemento en la dieta de  n-3 PUFA  sobre la transcriptoma muscular en ancianos "><img class="language-icon image-style-none" typeof="foaf:Image" src="https://www.mysprintt.eu/sites/all/modules/languageicons/flags/es.png" width="24" height="18" alt="Español" title="Español" /></a></li><li class="fi last"><a href="/fi/effect-dietary-n-3-pufa-supplementation-muscle-transcriptome-older-adults?multilink=switch" class="language-link" xml:lang="fi" hreflang="fi" title="Effect of dietary n-3 PUFA supplementation on the muscle transcriptome in older adults"><img class="language-icon image-style-none" typeof="foaf:Image" src="https://www.mysprintt.eu/sites/all/modules/languageicons/flags/fi.png" width="24" height="18" alt="Suomi" title="Suomi" /></a></li></ul></div>
  </div></div></div></div>
    <div id="columns">
      <div class="columns-inner clearfix">

        <div id="content-column">
          <div class="content-inner">

            
            <section id="main-content" role="main">

                                            <header id="main-content-header" class="clearfix">

                                                       <div class="titolo-blue"><h1 id="page-title" >Effetto dell’assunzione con la dieta di supplementi di n-3 PUFA sul trascrittoma muscolare negli anziani</h1></div>
                    			                  
                  
                </header>
                            
                              <div id="content">
                  <div id="block-system-main" class="block block-system no-title odd first last block-count-7 block-region-content block-main" >  
  
  <article id="node-390" class="node node-tabs-article article odd node-lang-it node-full ia-n clearfix" role="article">
  
  
  
  <div class="node-content">
    <div class="field field-name-body field-type-text-with-summary field-label-hidden view-mode-full"><div class="field-items" id="md1"><div class="field-item even"><h3>J. Yoshino, G.I. Smith, S.C. Kelly, S. Julliand, D.N. Reeds, B. Mittendorfer</h3>
<p><em><span class="bold">Physiol Rep. 2016;4(11). pii: e12785</span></em></p>
<p>Dietary fish oil-derived n-3 PUFA supplementation can increase muscle mass, reduce oxygen demand during physical activity, and improve physical function (muscle strength and power, and endurance) in people. The results from several studies conducted in animals suggest that the anabolic and performance-enhancing effects of n-3 PUFA are at least in part transcriptionally regulated.</p>
<p>The effect of n-3 PUFA therapy on the muscle transcriptome in people is unknown. In this study, we used muscle biopsy samples collected during a recently completed randomized controlled trial that found that n-3 PUFA therapy increased muscle mass and function in 20 older adults (aged 60-85 year) to provide a comprehensive assessment of the effect of n-3 PUFA therapy on the skeletal muscle gene expression profile in these people.</p>
<p>&nbsp;Using the microarray technique, we found that several pathways involved in regulating mitochondrial function and extracellular matrix organization were increased and pathways related to calpain- and ubiquitin-mediated proteolysis and inhibition of the key anabolic regulator mTOR were decreased by n-3 PUFA therapy. However, the effect of n-3 PUFA therapy on the expression of individual genes involved in regulating mitochondrial function and muscle growth, assessed by quantitative RT-PCR, was very small.&nbsp;</p>
</div></div></div><div class="field field-name-field-comment field-type-text-long field-label-hidden view-mode-full"><div class="field-items" id="md5"><div class="field-item even"><p><strong><u>Comment</u></strong>: These results indicate that the beneficial effects of n-3 PUFA on muscle mass and function/physical performance may be in part transcriptionally regulated and involves gene set pathways related to mitochondrial function, structural support, and anabolic signaling and proteolysis. Although the effect of n-3 PUFA therapy on the expression of individual genes was small, a coordinated up- or downregulation of genes in specific pathways, identified by using the microarray technique, could have significant effects on muscle mass and function.</p>
</div></div></div><div class="field field-name-field-link-article field-type-link-field field-label-hidden view-mode-full"><div class="field-items" id="md4"><div class="field-item even"><a href="http://www.ncbi.nlm.nih.gov/pubmed/27252251" class="bold" target="_blank">LINK TO THE ORIGINAL ARTICLE</a></div></div></div><div class="field field-name-field-for-public field-type-taxonomy-term-reference field-label-hidden view-mode-full"><ul class="field-items"><li class="field-item even" id="md2"><a href="/it/tabs-categories/for-researcher" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">#for_researcher</a></li></ul></div>  </div>

  
  
  </article>

  </div><meta  itemscope="" itemid="https://www.mysprintt.eu/it/effetto-dell-assunzione-con-la-dieta-di-supplementi-di-n-3-pufa-sul-trascrittoma-muscolare-negli" itemref="md1 md3 md4 md5" /><meta  itemscope="" itemid="https://www.mysprintt.eu/it/tabs-categories/for-researcher" id="md3" itemref="md2" />                </div>
              
              <!-- Feed icons (RSS, Atom icons etc -->
              
            </section> <!-- /main-content -->

            
          </div>
        </div> <!-- /content-column -->

                <div class="region region-sidebar-second sidebar"><div class="region-inner clearfix"><section id="block-views-for-the-public-arg1-block-2" class="block block-views block-for-healthcare odd first last block-count-8 block-region-sidebar-second block-for-the-public-arg1-block-2" ><div class="block-inner clearfix">  
      <h2 class="block-title">Altri articoli</h2>
  
  <div class="block-content content"><div class="view view-for-the-public-arg1 view-id-for_the_public_arg1 view-display-id-block_2 block-for-healthcare-contain view-dom-id-90048967db472811323c748c12025398">
        
  
  
      <div class="view-content">
      <table  class="views-table cols-0">
       <tbody>
          <tr  class="odd row-block-for-public views-row-first">
                  <td  class="views-field views-field-title views-align-center">
            <a href="/it/identificare-la-fragilit-e-la-sarcopenia-negli-anziani-ospedalizzati">Identificare la fragilità e la sarcopenia negli anziani ospedalizzati</a>          </td>
              </tr>
          <tr  class="even row-block-for-public">
                  <td  class="views-field views-field-title views-align-center">
            <a href="/it/sestrine-sieriche-potenziale-molecola-predittiva-nella-sarcopenia-umana">Sestrine sieriche: potenziale molecola predittiva nella sarcopenia umana</a>          </td>
              </tr>
          <tr  class="odd row-block-for-public">
                  <td  class="views-field views-field-title views-align-center">
            <a href="/it/una-dieta-ricca-di-fibre-pu-mitigare-il-rischio-di-sarcopenia-risultati-dalla-coorte-di-anziani">Una dieta ricca di fibre può mitigare il rischio di sarcopenia: risultati dalla coorte di anziani europei NU-AGE</a>          </td>
              </tr>
          <tr  class="even row-block-for-public">
                  <td  class="views-field views-field-title views-align-center">
            <a href="/it/associazione-tra-abitudini-alimentari-e-funzione-fisica-nelle-donne-anziane-italiane-e-brasiliane">Associazione tra abitudini alimentari e funzione fisica nelle donne anziane italiane e brasiliane</a>          </td>
              </tr>
          <tr  class="odd row-block-for-public">
                  <td  class="views-field views-field-title views-align-center">
            <a href="/it/modelli-sperimentali-di-sarcopenia-collegare-il-meccanismo-molecolare-e-la-strategia-terapeutica">Modelli sperimentali di sarcopenia: collegare il meccanismo molecolare e la strategia terapeutica</a>          </td>
              </tr>
          <tr  class="even row-block-for-public views-row-last">
                  <td  class="views-field views-field-title views-align-center">
            <a href="/it/interventi-nutrizionali-migliorare-la-massa-muscolare-la-forza-muscolare-e-la-performance-fisica">Interventi nutrizionali per migliorare la massa muscolare, la forza muscolare e la performance fisica negli anziani: una revisione di revisioni sistematiche e meta-analisi</a>          </td>
              </tr>
      </tbody>
</table>
    </div>
  
      <div class="item-list item-list-pager"><ul class="pager"><li class="pager-previous even first">&nbsp;</li><li class="pager-current odd">1 di 35</li><li class="pager-next even last"><a href="/it/effetto-dell-assunzione-con-la-dieta-di-supplementi-di-n-3-pufa-sul-trascrittoma-muscolare-negli?page=1">next ›</a></li></ul></div>  
  
  
  
  
</div></div>
  </div></section></div></div>
      </div>
    </div> <!-- /columns -->

    
    <!-- four-4x25 Gpanel -->
    
          <footer id="footer" role="contentinfo">
        <div id="footer-inner" class="clearfix">
          <div class="region region-footer"><div class="region-inner clearfix"><section id="block-block-2" class="block block-block destra marginato1 footer odd first block-count-9 block-region-footer block-2" ><div class="block-inner clearfix">  
      <h2 class="block-title">Contacts</h2>
  
  <div class="block-content content"><p><img alt="" src="/sites/default/files/email-icon.png" style="width: 20px; height: 14px; vertical-align: middle;"> E-mail: <a href="mailto:sprintt-Info@mysprintt.eu?subject=From%20Web%20Site">sprintt-Info@mysprintt.eu</a></p>
<p><img alt="" src="/sites/default/files/email-icon.png" style="width: 20px; height: 14px; vertical-align: middle;"> E-mail: <a href="mailto:sprintt-press@mysprintt.eu">sprintt-press@mysprintt.eu</a></p>
<p><img alt="" src="/sites/default/files/login_0.png" style="width: 25px; height: 28px; vertical-align: middle;"> <a href="/user">My-Sprintt staff access</a></p>
<p><img alt="" src="/sites/default/files/login_0.png" style="width: 25px; height: 28px; vertical-align: middle;"> <a href="https://wssemea-ext.sanofi.com/ws/IMI-PFnS/default.aspx" target="_blank">Partner Portal</a></p>
<div id="dc_vk_code" style="display:none">&nbsp;</div>
</div>
  </div></section><section id="block-views-tracker-block-1" class="block block-views destra marginato1 even block-count-10 block-region-footer block-tracker-block-1" ><div class="block-inner clearfix">  
      <h2 class="block-title">Last update</h2>
  
  <div class="block-content content"><div class="view view-tracker view-id-tracker view-display-id-block_1 destra view-dom-id-6d07de70d07b316b19c1b6ad8125f0e3">
        
  
  
      <div class="view-content">
        <div class="views-row views-row-1 views-row-odd views-row-first views-row-last">
      
  <div class="views-field views-field-changed">        <span class="field-content">Mercoledì, 17 Novembre, 2021 - 14:56</span>  </div>  </div>
    </div>
  
  
  
  
  
  
</div></div>
  </div></section><section id="block-counter-counter" class="block block-counter destra odd block-count-11 block-region-footer block-counter" ><div class="block-inner clearfix">  
      <h2 class="block-title">Counter</h2>
  
  <div class="block-content content"><div  id="counter"><ul><li>Site Counter:<strong>1,285,173</strong></li><li>Visitors:</li><ul><li>Today:<strong>126</strong></li><li>This week:<strong>2,937</strong></li><li>This month:<strong>11,939</strong></li><li>This year:<strong>95,466</strong></li></ul></ul></div></div>
  </div></section><section id="block-block-3" class="block block-block footer even last block-count-12 block-region-footer block-3" ><div class="block-inner clearfix">  
      <h2 class="block-title">Site-map</h2>
  
  <div class="block-content content"><p style="text-align:left;"><img alt="" src="/sites/default/files/icon_sitemap.png" style="width: 31px; height: 31px; vertical-align: middle;"><span style="font-size:11px;"><a href="./site-map">Site-map</a></span></p>
<p style="text-align:left;"><span style="font-size:11px;"><img alt="" src="/sites/default/files/icon_privacy.png" style="width: 24px; vertical-align: middle;"> <a href="./credits-disclaimer-copyright">Disclaimer,<br><br />
	credits &amp; Copyright</a></span></p>
<div id="dc_vk_code" style="display:none">&nbsp;</div>
</div>
  </div></section></div></div>          <p class="attribute-creator"></p>
        </div>
      </footer>
    
  </div> <!-- /page -->
</div> <!-- /texture overlay -->

  <script type="text/javascript">
<!--//--><![CDATA[//><!--
function euCookieComplianceLoadScripts() {}
//--><!]]>
</script>
<script type="text/javascript">
<!--//--><![CDATA[//><!--
var eu_cookie_compliance_cookie_name = "";
//--><!]]>
</script>
<script type="text/javascript" src="https://www.mysprintt.eu/sites/default/files/js/js_07imHaZmg-ev-iThT1TUpbMvXdOf0JOKCXRbJcq-XRk.js"></script>
<script type="text/javascript" src="https://www.mysprintt.eu/sites/default/files/js/js_2lJC5gTZ8B3-P19n2LPEd0viiCEmLJ5gcIAFYex1r0U.js"></script>
</body>
</html>